Omics · study · 2026
Transcriptomic profiling of thalamic tissue from APOE4-carrying 5xFAD mice with or without Lilrb4a deficiency
Listed in NCBI GEO
The microglial immune receptor Lilrb4a is strongly induced in Alzheimer’s disease (AD) mouse models and has been proposed to function as a receptor for APOE4.
Description
To define the molecular programs associated with Lilrb4a deficiency in an APOE4-dependent AD context, we conducted bulk RNA-seq on thalamic tissue from 5xFAD mice carrying human APOE4 (5EL) and Lilrb4a-deficient 5EL mice (5ELKO). Transcriptomic analysis identified significant changes in inflammatory and metabolic pathways, with prominent enrichment of PPAR signaling and broader lipid/energy metabolic programs in Lilrb4a-deficient mice.
This dataset provides a transcriptomic resource for investigating Lilrb4a-dependent molecular pathways in APOE4-associated AD-like pathology.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324957 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324957 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1438147 ncbi.nlm.nih.gov/bioproject/PRJNA1438147 ↗
project · from NCBI GEO
- PubMed 42330346 pubmed.ncbi.nlm.nih.gov/42330346 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE324957 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |