Omics · study · 2026
Multi-omic analysis reveals molecular subtypes with distinct immunological phenotypes in SLE [RNA-Seq]
Listed in NCBI GEO
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by variability in clinical manifestations and underlying molecular mechanisms.
Description
To investigate this heterogeneity, we performed integrative multi-omic profiling—including epigenomic (EM-seq), transcriptomic (RNA-seq), and proteomic (Olink) analyses—on whole blood samples from over 700 SLE patients enrolled in two Phase III clinical trials.
Using this approach, we identified three stable molecular endotypes of SLE, providing a framework for understanding disease subtypes and informing precision medicine strategies.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319130 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319130 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1422154 ncbi.nlm.nih.gov/bioproject/PRJNA1422154 ↗
project · from NCBI GEO
- PubMed 42039161 pubmed.ncbi.nlm.nih.gov/42039161 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · Genetics 69% · RNA sequencing 65%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319130 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |