Omics · study · 2026
Effect of depletion of POLDIP2 on gene expression during spermatogenesis in mouse testes
Listed in NCBI GEO
POLDIP2, as a mitochondrial protein, is essential for male fertility.
Description
In our study, we found that the depletion of POLDIP2 caused accumulation of mitochondrial ribosomes and dramatic impairment of electron chain Complex IV in mouse testes. To determine the molecular mechanism after the depletion of POLDIP2, total RNA was extracted from mouse testes at postnatal day 35 and sequenced to identify the differential gene expression between wildtype and Poldip2 KO testes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE292nnn/GSE292916 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292916 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1241866 ncbi.nlm.nih.gov/bioproject/PRJNA1241866 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE292916 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |