Raster · study · 2026
High-Resolution Spatial Transcriptomics of Irradiated Mouse Submandibular Gland Treated with Ep-FH
Listed in NCBI GEO
Our previous studies developed a novel scaffold by chemically conjugating laminin-1 peptides (A99 and YIGSR) and growth factors, FGF-7 and FGF-10, to fibrin hydrogels (Ep-FH).
Description
The resulting hydrogel, Ep-FH applied via a single intraglandular injection to irradiated mouse submandibular gland (SMG), enhanced epithelial tissue organization while promoted secretory function after 60 days of treatment. Together these results suggest a remarkable potential for clinical applications; however, before applying Ep-FH in a clinical setting, it is necessary to understand how the treatment affects different cell populations within SMG.
Therefore, the goal of this study was to perform high-resolution spatial transcriptomics (Xenium 10 Genomics) to characterize how treatment with Ep-FH alters irradiated mouse SMG cell populations as well as relevant signaling mechanisms.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314531 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314531 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1391467 ncbi.nlm.nih.gov/bioproject/PRJNA1391467 ↗
project · from NCBI GEO
Topics
- Stated by source
- Mus musculus · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE314531 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |