Omics · study · 2026
Clofazimine induced changes in the host immune system
Listed in NCBI GEO
Clofazimine (CLO), an antibiotic drug has been in use as such for more than 50 years to treat Mycobacterium leprosae and MDR Mycobacterium tuberculosis infections in humans.
Description
Long suspected and proven during the COVID pandemic the drug also has a secondary function as a modulator of the host immune system. We want to measure changes in the transcriptome of cells (bulk RNAseq) treated with CLO at t=6h where we see the onset of phenotypic changes in these cells without the typical cell death induced at higher CLO concentrations over a longer period of time.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294972 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294972 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1252130 ncbi.nlm.nih.gov/bioproject/PRJNA1252130 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE294972 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |