Omics · study · 2026
Transcriptomic profiling of neonatal mouse ventricular myocytes (NMVMs) under hypoxia and recombinant Serglycin stimulation
Listed in NCBI GEO
To investigate the direct regulatory effects of Serglycin (SRGN) on cardiomyocytes under ischemic conditions, we performed bulk RNA-sequencing on primary neonatal mouse ventricular myocytes (NMVMs).
Description
The study includes three experimental groups: Control (Con), Hypoxia, and Hypoxia + recombinant SRGN (rSRGN). NMVMs in the Hypoxia and Hypoxia+rSRGN groups were subjected to oxygen-glucose deprivation (glucose-free and serum-free DMEM) in an anaerobic environment (AnaeroPack-MIC, Mitsubishi A-07) for 6 hours.
This dataset identifies the transcriptional alterations driven by SRGN in cardiomyocytes during hypoxic stress.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318951 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318951 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1420871 ncbi.nlm.nih.gov/bioproject/PRJNA1420871 ↗
project · from NCBI GEO
- PubMed 42327787 pubmed.ncbi.nlm.nih.gov/42327787 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE318951 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |