Data · dataset · 2025
Myosteatosis is associated with reduced survival in patients with pancreatic adenocarcinoma undergoing curative intent resection
Listed in Teesside University Research Data Repository
We included 203 patients undergoing curative-intent surgery for PDAC between 2011 and 2022.
Description
Autosegmentation of cross-sectional CT slices quantified skeletal muscle area and fat infiltration to identify patients with sarcopenia and myosteatosis. Cox proportional hazards modeling was used to evaluate survival.
Pre-operative serum and intra-operative rectus abdominis biopsies underwent metabolomic and transcriptomic profiling, respectively. Of 203 patients, 116 had sarcopenia and 120 had myosteatosis. Median follow-up was 33.5 months.
Read the rest (2 more)
On multivariable analysis, myosteatosis but not sarcopenia predicted shorter OS, with the association limited to male patients with myosteatosis (median OS 16.3 vs 39.9 months, log-rank P<0.001). In 57 muscle transcriptomes, sex explained the largest variance, with <1% overlap in myosteatosis-related differentially expressed genes between sexes and <15% for sarcopenia. EnrichR and Ingenuity Pathway Analysis revealed upregulation of pro-inflammatory pathways in males and downregulation in females with myosteatosis.
Serum metabolomics revealed altered glutathione metabolism in both sexes. Transcriptomic data can be found at: ncbi.nlm.nih.gov/sra/PRJNA1315257
Links
Where it is published
- DOI doi.org/10.17632/gmwsn6tzy9.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Medicine & Health · Social Science
- Inferred from text
- Computed tomography 50% · Oncology and carcinogenesis 71%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/gmwsn6tzy9.1 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].anzsrc:group:3211 | enrichment · researchdata tees ac uk | taxonomy-embedding@1.0.0 | title+keywords+description (71%) |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[modality].local:modality:ct | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (50%) |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |