Omics · study · 2026
Competition for H2A.Z Between IAP Elements and Gene Promoters is Governed by ANP32E
Listed in NCBI GEO
The histone variant H2A.Z is the most evolutionarily conserved histone protein and among the most well studied chromatin factors in biology, yet several unknowns remain, including the role of H2A.Z in transcriptional regulation and its function at heterochromatic repetitive loci.
Description
We find that H2A.Z accumulates at a subset of endogenous retrotransposons, including IAP elements, upon their transcriptional activation, and this build-up occurs at the expense of H2A.Z levels over gene promoters.
We also find that the H2A.Z removal chaperon ANP32E allows these changes to occur by permitting repetitive elements to gain access to surplus H2A.Z which is not installed at gene promoters. Our results are consistent with a model in which H2A.Z supports transcriptional activation of repetitive elements, and competition for H2A.Z between promoters and repetitive elements underlies transcriptome-wide response to retrotransposon reactivation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE237nnn/GSE237806 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE237806 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA996648 ncbi.nlm.nih.gov/bioproject/PRJNA996648 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Genetics 71%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE237806 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |