Excel · study · 2026
Effect of adiponectin receptor agonist AdipoRON on breast cancer cell lines
Listed in NCBI GEO
Various adipocyte-derived adipokines reportedly regulate cancer growth, but their underlying mechanisms and cancer types suited for therapeutic interventions remain unknown.
Description
We analyzed adipokine receptor expression across cancer types and found that breast cancer cells express remarkably high levels of Adiponectin receptor 1. Adiponectin receptor stimulation decreased the proliferation and migratory ability of hormone receptor (HR)-positive and triple-negative breast cancer cell lines while activating apoptosis.
Combination treatment with adiponectin receptor stimulants and existing drugs additively inhibited cell proliferation. Gene expression analysis revealed that adiponectin receptor stimulation regulates ferroptosis as well as ER expression in breast cancer cell lines. In conclusion, adiponectin receptor stimulation suppresses tumor growth across genetic breast cancer subtypes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE290nnn/GSE290491 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290491 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1228253 ncbi.nlm.nih.gov/bioproject/PRJNA1228253 ↗
project · from NCBI GEO
- PubMed 41888104 pubmed.ncbi.nlm.nih.gov/41888104 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE290491 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |