Table 1_Model-based integration of chimeric antigen receptor T-cell kinetics and tumor features to predict therapeutic outcomes in patients with B-cell malignancies.xlsx

Although multiple covariates and risk scores exist, their prognostic accuracy remains limited.</p>Methods<p>We prospectively measured CAR T-cell kinetics in peripheral blood of 92 patients with B-cell malignancies using multicolor flow cytometry.

To explore underlying mechanisms, we developed a mechanistic model of CAR T-cell and tumor cell interactions.</p>Results<p>We captured four phases of CAR T-cell kinetics in peripheral blood: distribution, expansion, contraction, and persistence. Patients with weak expansion or deep contraction are more likely to relapse. When fitted to the 46 patients with suDicient data points, the model reproduces individual CAR T-cell kinetics but fails to predict outcomes using uniform tumor parameters.