Highly multiplexed spatial analysis identifies tissue-resident memory T cells as drivers of ulcerative and immune checkpoint inhibitor induced colitis

R script for data normalization, scaling, cell type annotation and analysis is publicly available at Zenodo (DOI: 10.5281/zenodo.7858216).

In this Verse, raw data and corresponding meta data as outlined below have been deposited. Type of dataset: restricted data (template 3b) =============================== Imaging mass cytometry data (after single-cell segmentation) -- segmented_IMC_data.Rda (restricted) This file contains the raw single-cell segmented channel data for all IMC channels including geometric cell data. -- IMC_clinical_metadata.csv (restricted) This file contains clinical metadata for the subjects included in segmented_IMC_data.Rda -- IMC_clinical_metadata_codebook.csv (unrestricted) This file contains codebook with description of all parameters included IMC_clinical_metadata.csv Serum multiplexed proteomic (Olink) data -- Olink_data.csv (restricted) This file contains raw protein data (serum protein levels) and clinical metadata. -- Olink_data_codebook.csv (unrestricted) This file contains codebook with description of all parameters included Olink_data.csv - Patient informed consent form -- PIF_v7_UNICIT.pdf (restricted) This file contains the original informed consent form that relates to the UNICIT biobank study as described in the original manuscript.