Synergistic Ultrasound-Activable Artificial Enzyme and Precision Gene Therapy to Suppress Redox Homeostasis and Malignant Phenotypes for Controllably Combacting Hepatocellular Carcinoma

Multi-modal therapeutics for HCC have attracted increasing attention. However, designing a nanotherapeutic platform with effective chem-/sono- double-modal HCC therapies is still challenging.

Here, we first designed a novel porphyrin-based nanomase (Porzyme) P-Por-Os with nano-sonosensitivity for HCC therapy. Endowed with a large hollow spherical structure of poly porphyrins, which efficiently improved the electron transport capacity of polyporphyrins and exposed the active site of superficial metal atoms, P-Por-Os effectively catalyzed the production of ROS from H2O2. This so-called Chemodynamic Therapy (CDT) was further significantly reinforced by Sonodynamic Therapy (SDT) and achieving this therapeutic ultrasound-controlled anti-tumor effects in HCC.