Omics · study · 2026
Protective Mechanisms of SP1-Induced PRDX6 Expression Against Ferroptosis in Retinal Pigment Epithelium
Listed in NCBI GEO
Description
Background
Retinitis pigmentosa is a polygenic genetic disease for which night blindness and progressive visual field shrinkage are the primary clinical manifestations. The pathogenesis of retinitis pigmentosa involves pathological changes in photoreceptor and retinal pigment epithelium (RPE) cells. Ferroptosis, a form of programmed cell death distinct from apoptosis, is related to retinitis pigmentosa via certain pathological mechanisms.
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PRDX6 is a negative regulator of ferroptosis, the expression of which is modulated by SP1. In this study, we investigated the protective mechanism of PRDX6 on retinitis pigmentosa, and examined the guiding effect of SP1.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315262 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315262 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1395516 ncbi.nlm.nih.gov/bioproject/PRJNA1395516 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE315262 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |