Data Sheet 1_A case report: axillary ALK-positive anaplastic large-cell lymphoma mimicking an infectious abscess in an adolescent.pdf

Histopathology of the solid tissue demonstrated large pleomorphic lymphoid cells, and immunohistochemistry showed strong CD30 and ALK expression, establishing ALK-positive ALCL. The patient was transferred to hematology and received initial cytoreductive therapy with brentuximab vedotin and short-course zeprumetostat, after which the local tumor burden decreased and delayed wound closure was performed. She subsequently received five cycles of brentuximab vedotin plus CHP and chidamide maintenance after complete remission.</p>Conclusion<p>A presumed abscess that yields little pus but contains solid friable tissue should not be managed as infection alone.

In refractory, culture-negative, or biologically discordant soft-tissue lesions, early biopsy of the cavity wall and solid components may help reduce diagnostic delay and redirect care toward malignancy-specific treatment.</p>