Table · dataset · 2026
Long-term antiviral therapy fails to resolve the persistent plasma cytokines and virome dysregulations in HIV-1 infection
Listed in HKU DataHub and figshare and Loughborough Research Repository and UP Research Data Repository — shown once because both records carry DOI 10.6084/m9.figshare.32390040.v2
<p dir="ltr">In the era of antiretroviral therapy (ART), persistent immune activation and inflammation increase the risk of non-AIDS-related complications in people living with HIV (PLWH), representing a major challenge in AIDS treatment.
Description
HIV-1 infection disrupts cytokine network and plasma virome, yet the long-term impact of ART on them and their relationship with immune activation remain poorly understood. Here, we characterized the immune profiles and plasma virome in PLWH on ART for 5–20 years using metagenomic sequencing and multiplex immunoassays.
Cytokines IL-10, VEGF, GM-CSF, GM-CSF, PDGF-BB, FGF basic and IL-1rα remained significantly elevated (5.3- to 27.9-fold), whereas IL-12 and IL-4 remained significantly decreased (1.4- to 2.6-fold) during long-term ART compared with healthy controls.<b> </b>ART declined anellovirus abundance but increased the positive rate and abundance of human pegivirus 1 (HPgV-1). Specific anellovirus species strongly correlated with elevated IL-10, GM-CSF, and VEGF.
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Pooled anellovirus peptide library induced increased IFN-γ secretion in multiple immune cell subsets and promoted early Th1 cell activation. A combination of two anelloviruses and three cytokines showed strong power to discriminate immune non-responders (INR) from immune responders (IR).<b> </b>These findings indicate that long-term ART does not fully restore the homeostasis of cytokine network and plasma virome in PLWH.
Persistently elevated cytokines (e.g. IL-10 and VEGF) provide a plausible explanation for the high risk of non-AIDS-related comorbidities and represent potential intervention targets for adjunctive therapeutic strategies to improve immune recovery in PLWH.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.32390040.v2 ↗
DOI / persistent id · from datahub hku hk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from datahub hku hk
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Engineering · Humanities · Humanities · Humanities · Life Sciences · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medical virology · Medical virology · Medical virology · Medical virology · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science · Social Science
- Inferred from text
- Sequencing 75%
Provenance · 4 source records, 41 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| HKU DataHub | oai:figshare.com:article/32390040 | 7 d ago | JSON v1 |
| figshare | oai:figshare.com:article/32390040 | 7 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/32390040 | 6 d ago | JSON v1 |
| UP Research Data Repository | oai:figshare.com:article/32390040 | 6 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].anzsrc:field:320705 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Medical virology'] |
| concepts[field].anzsrc:field:320705 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Medical virology'] |
| concepts[field].anzsrc:field:320705 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Medical virology'] |
| concepts[field].anzsrc:field:320705 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Medical virology'] |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[modality].local:modality:sequencing | enrichment · datahub hku hk | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/description |
| license | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/rights |
| publication_date | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| title | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/title |