8 datasets

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">This dataset contains molecular dynamics (MD) trajectory movies and associated cluster-resolved data for five flaviviral NS5–ligand complexes investigated using molecular dynamics, binding-site-guided conformational clustering, quantum mechanics/molecular mechanics (QM/MM) calculations, and local vibrational mode analysis (LMA).</p><p dir="ltr">The five systems are: (1) dengue virus (

ZivaHub + HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">病毒性心肌炎（VMC）是一种由病毒复制和宿主炎症反应共同驱动的炎症性心脏疾病。柯萨奇病毒B3（CVB3）是VMC的主要致病原体之一。目前的抗病毒疗法在纠正感染后免疫炎症失调和心肌修复障碍方面仍有限。以往的研究，包括我们的初步发现，已证明瓜氨酸对心血管菌感染具有抗病毒活性;然而，单用时其抗病毒疗效仍然相对有限。因此，在本研究中，我们旨在寻找能够增强瓜氨酸抗CVB3作用的抗病毒组合策略。 通过<i>外</i>筛查多种抗病毒化合物与瓜氨酸联合使用，硼比醇盐酸盐（AH）和利巴韦林（RBV）被确定为具有增强抗心血管蛋白活性的候选组合方案。 <i>体外</i>实验进一步表明，瓜氨酸与AH或RBV联合使用比单药更有效地抑制CVB3复制。在感染CVB3的小鼠中，联合AH和瓜氨酸治疗提高了生存率并缓解了心肌损伤。机制分析显示，这种组合与巨噬细胞极化逆转、肠道微生物稳态恢复相关，且有

ZivaHub + HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">This dataset contains processed single-nucleus RNA sequencing (snRNA-seq) data generated from heart tissues of coxsackievirus A6 (CVA6)-infected wild-type (WT) and Ifnar1-deficient mice. Heart tissues were collected at 5 days post-infection (dpi). Six independent biological samples were included, comprising three CVA6-infected WT mice and three CVA6-infected Ifnar1-deficient mice, wit

HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">In the era of antiretroviral therapy (ART), persistent immune activation and inflammation increase the risk of non-AIDS-related complications in people living with HIV (PLWH), representing a major challenge in AIDS treatment. HIV-1 infection disrupts cytokine network and plasma virome, yet the long-term impact of ART on them and their relationship with immune activation remain poorly

figshare2026 · Astronomical catalogue

<p dir="ltr">Differentiated normal human bronchial epithelial cells (NHBE) were infected with SARS-CoV (strain: HK39849) or SARS-CoV-2 (strain: hCoV-19/Hong Kong/VM0001061/ 2020) at an MOI of 0.5 or MOCK-infected with PBS, and were collected at 2h, 6h, 24h, 48h, and 72h post-infection (hpi) to determine viral load and host response by TCID50 and bulk RNA sequencing (RNAseq), respectively. Male Syr

figshare2026 · Astronomical catalogue

<p dir="ltr">Dengue is a rapidly spreading disease transmitted by mosquitoes and is caused by the <i>Dengue virus</i> (DENV), affecting approximately 390 million individuals globally. The only vaccine approved by the FDA, Dengvaxia, has limited effectiveness and is not authorized for use in India. Tomatidine, a steroidal alkaloid obtained from <i>Solanum</i> species, has demonstrated broad-spectru

figshare2026 · Astronomical catalogue

<p dir="ltr">Data ser HPV and ITS</p>

figshare2026 · Astronomical catalogue

<p dir="ltr">This study's data demonstrates widespread serological evidence of prior SARS-CoV-2 exposure and vaccine-induced immunity in both urban and rural Ghana. Functional neutralising antibodies were detected in a longitudinal subset, suggesting persistence of antibody-mediated protection in some individuals. Larger longitudinal studies with repeated functional immune assessments are needed t