Text · study · 2026
Functional Analysis of Hepatocyte Host Factor A1BG in Antiviral and Antitumor Effects
Listed in NCBI GEO
To investigate the biological function of A1BG in HepG2 cells, we employed siRNA-mediated knockdown and plasmid-based overexpression approaches to modulate A1BG expression.
Description
Global gene expression changes associated with altered A1BG expression were subsequently examined using RNA microarray analysis. We found that differentially expressed genes associated with A1BG overexpression were predominantly enriched in pathways related to antiviral and antitumor responses, including the Th1/Th2 signaling pathway, FGFR1 ligand binding and activation, and activation of matrix metalloproteinases.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314415 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314415 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1390890 ncbi.nlm.nih.gov/bioproject/PRJNA1390890 ↗
project · from NCBI GEO
- PubMed 41749914 pubmed.ncbi.nlm.nih.gov/41749914 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE314415 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |