Excel · study · 2026
Pim1 exacerbates inflammatory arthritis by mediating Th17 differentiation
Listed in NCBI GEO
The present study demonstrated that pim1-promoted mito-Ca2+ influx enhanced the activity of mitochondrial OXPHOS, bringing about the differentiation of Th17 and driving the pathogenic progression of inflammatory arthritis.
Description
Targeting pim1 impeded Th17 differentiation and alleviated collagen-induced arthritis (CIA) and SKG arthritis, suggesting that Pim1 is a target for the treatment of inflammatory arthritis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE261nnn/GSE261671 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE261671 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1088323 ncbi.nlm.nih.gov/bioproject/PRJNA1088323 ↗
project · from NCBI GEO
- PubMed 41767599 pubmed.ncbi.nlm.nih.gov/41767599 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE261671 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |