Omics · study · 2026
Detection of transcriptomic changes in N9 and N33 GBM cells following treatment with small molecular inhibitors of MK-0752, WP1066 and retinoic acid
Listed in NCBI GEO
We demonstrated that the cell state of suppressed neurogenesis and precocious astrogenesis in IDH-wildtype glioblastoma (GBM) could be manipulated as a potential therapeutic option.
Description
Clinically tested small molecule inhibitors MK-0752 (MK), WP1066 (WP), and retinoic acid (RA) were used to induce de-repression of neuronal differentiation in IDH-wildtype GBM. In order to explore the pathways affected by the two-drug (combination of MK and WP) or three-drug (combination of MK, WP, and RA) treatment, we performed mRNA sequencing on N9 and N33 cells at 48 hours post two-drug or three-drug treatent.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324741 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324741 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1436942 ncbi.nlm.nih.gov/bioproject/PRJNA1436942 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 69% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE324741 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |