Omics · study · 2026
DNA Methylation in Blood Samples from Malignant Mammary Tumors of Companion Dogs: An Epigenetic Perspective
Listed in NCBI GEO
Canine mammary gland tumors (cMGTs) are neoplasms arising from mammary epithelial or supporting tissues and account for approximately 50–70% of all tumors in intact female dogs.
Description
Epigenetic regulation, such as DNA methylation, has been investigated to elucidate the molecular mechanisms of cMGTs. This study explored whether DNA methylation alterations in peripheral blood reflect tumor-related epigenetic patterns.
Twenty client-owned dogs were enrolled, including ten with cMGTs and eight healthy controls. Although no individual genes reached statistical significance after multiple testing correction, exploratory gene ontology (GO) analysis identified 22 biological processes showing potential enrichment, including two hypermethylated and twenty hypomethylated regions. Comparative analysis between canine and human datasets revealed 91 overlapping hypomethylated genes displaying consistent patterns across both species.
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The top enriched GO terms were morphogenesis of an epithelium and cell growth. These findings provide exploratory evidence that blood-based DNA methylation profiling may capture tumor-associated epigenetic alterations in cMGTs.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316492 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316492 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1402999 ncbi.nlm.nih.gov/bioproject/PRJNA1402999 ↗
project · from NCBI GEO
- PubMed 42146898 pubmed.ncbi.nlm.nih.gov/42146898 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by genome tiling array
- From keywords
- Life Sciences
- Inferred from text
- DNA methylation profiling 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE316492 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-genome-tiling-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].local:method:dna-methylation-profiling | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |