Omics · study · 2026
DNA methylation profiling of PBMCs from 42 esophageal squamous cell carcinoma patients and 30 controls using the Illumina MethylationEPIC array
Listed in NCBI GEO
Esophageal squamous cell carcinoma (ESCC) constitutes over 80% of esophageal cancer cases in China, with advanced-stage patients exhibiting a 5-year survival rate below 30%.
Description
Early diagnosis is critical for improving survival outcomes. Current clinical diagnostic methods present significant limitations.
This study aimed to identify potential non-invasive biomarkers through epigenomic analysis of the DNA methylome in peripheral blood mononuclear cells (PBMCs) from ESCC patients. Using the Infinium MethylationEPIC (935K) array, we profiled genome-wide DNA methylation patterns in PBMCs from 42 ESCC patients and 30 controls. We discovered an episignature of 742 differentially methylated CpGs (DMCs) that effectively discriminates ESCC patients from controls.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE302nnn/GSE302955 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302955 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1292891 ncbi.nlm.nih.gov/bioproject/PRJNA1292891 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by array
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · DNA methylation profiling 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE302955 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].local:method:dna-methylation-profiling | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |