Omics · study · 2026
Bulk RNA sequencing of whole-blood leukocytes from specific pathogen-free and IMPACT4-exposed mice
Listed in NCBI GEO
Specific pathogen-free laboratory mice exhibit limited immune maturation because of restricted microbial exposure.
Description
To determine how exposure to a defined consortium of enteric microbes alters systemic transcriptional programs, whole blood was collected from specific pathogen-free control mice and mice exposed to the IMPACT4 microbial consortium. RNA was extracted from the blood leukocytes and subjected to bulk RNA sequencing.
Gene-expression profiles were compared between the two experimental groups to characterize transcriptional programs associated with microbial exposure and systemic immune maturation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338940 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338940 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1494533 ncbi.nlm.nih.gov/bioproject/PRJNA1494533 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE338940 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |