Omics · study · 2026
Effect of different ECM proteins on cholangiocytes phenotype in a double-spheroids model
Listed in NCBI GEO
Cholangiocyte plasticity is strongly influenced by the extracellular matrix (ECM) niche.
Description
To investigate how specific ECM components modulate cholangiocyte identity, we performed bulk RNA sequencing on double-spheroid cultures composed of normal mouse cholangiocytes embedded either in collagen I alone or in a laminin-rich matrix. Laminin-containing ECM preserves cholangiocyte identity and limits hepatocyte-like transcriptional programs.
This dataset provides transcriptional profiling of cholangiocytes exposed to distinct ECM environments and supports mechanistic studies on ECM-driven regulation of ductular reaction fate.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313120 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313120 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1378575 ncbi.nlm.nih.gov/bioproject/PRJNA1378575 ↗
project · from NCBI GEO
- PubMed 41905508 pubmed.ncbi.nlm.nih.gov/41905508 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 70% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE313120 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |