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Omics · study · 2026

Helicobacter pylori infection-induced succinate accumulation drives IBS-D via KAT2A-mediated H3K79 succinylation

Listed in NCBI GEO

To explore the molecular mechanisms underlying Helicobacter pylori (Hp)-induced diarrhea-predominant irritable bowel syndrome (IBS-D), C57BL/6 mice were allocated into normal control (NC), Hp-infected, and succinate-treated (SA) groups.

Description

Alterations in colonic motility and visceral hypersensitivity were then assessed. Comparative RNA-sequencing (RNA-seq) of colonic tissues was performed to identify differentially expressed genes and elucidate the downstream molecular effectors mediating luminal succinate-driven dysmotility

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Stated by source
Expression profiling by high throughput sequencing · Mus musculus
From keywords
Life Sciences
Inferred from text
RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE33869912 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (65%)
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title