Omics · study · 2026
Inertia-driven, self-powered electrotherapy for enhanced wound regeneration
Listed in NCBI GEO
Skin serves as the primary barrier against hazardous substances, and timely wound closure is an essential initial step in wound regeneration.
Description
However, intrinsic skin regenerative capacity is severely limited in critical-size acute wounds due to insufficient cell migration and tissue regeneration. Electrical stimulation restores endogenous wound electric fields and promotes cell migration and proliferation, thereby accelerating wound regeneration.
Repetitive stimulation with identical electrical waveforms may attenuate electrophysiological responsiveness. Here, we present a miniaturized, lightweight, inertia-driven triboelectric nanogenerator–based electroceutical platform (2 cm3, 4.9 g) that enables self-powered operation with bioresorbable electrodes. In vitro studies demonstrate that electric fields and charges enhance cell migration and exosome secretion.
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In vivo animal studies confirm that motion-modulated, electrical waveforms delivered to the wound bed promote angiogenesis and epidermal maturation and stabilize the wound-associated microbiome. Collectively, these findings establish an electroceutical strategy for effective wound management in aging and impaired healing environments.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326090 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326090 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1443318 ncbi.nlm.nih.gov/bioproject/PRJNA1443318 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Non-coding RNA profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326090 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:non-coding-rna-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |