Genome-wide methylation analysis defines the epigenetic identity of human innate lymphoid cells

Identifying differentially methylated regions within immune cell lineages contributes to their phenotypic and functional characterization, leading to a better understanding of lineage-specific transcriptional regulation. Here, we performed a genome-wide methylation analysis of human innate lymphoid cells (ILCs) isolated from tonsils and blood samples of healthy donors, which allowed us to define specific epigenetic marker regions for ILC1, ILC2 and ILC3.