Omics · study · 2026
GLAST-positive small extracellular-vesicle small RNA sequencing in amyotrophic lateral sclerosis: a paired 60-participant discovery cohort
Listed in NCBI GEO
Small-RNA sequencing of a plasma-derived, GLAST-positive small extracellular-vesicle fraction was performed in a discovery cohort of 60 participants, including 45 participants with amyotrophic lateral sclerosis (ALS) and 15 non-neurological controls.
Description
One small-RNA sequencing library was generated per participant using the QIAseq miRNA Library Kit and sequenced on an Illumina NovaSeq 6000 at the Yale Center for Genome Analysis.
This Series contains the miRNA-seq data. Matched total-RNA sequencing was performed from the same vesicle RNA eluate and is deposited in a companion GEO Series. The data were generated to characterize extracellular-vesicle RNA cargo and identify molecular features associated with ALS and clinical progression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346895 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346895 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1526786 ncbi.nlm.nih.gov/bioproject/PRJNA1526786 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Non-coding RNA profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE346895 | 8 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:non-coding-rna-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |