Omics · study · 2026
RNA-seq of bronchoalveolar lavage cells from wild-type mice reconstituted with wild-type or Cry1/2 double-knockout bone marrow.
Listed in NCBI GEO
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disease characterized by alveolar destruction and impaired tissue repair.
Description
Although circadian disruption has been implicated in COPD pathogenesis, the underlying molecular mechanisms remain poorly understood. To examine the hematopoietic contribution of CRY1/2 to lung homeostasis, we generated bone-marrow–chimeric mice by retro-orbitally injecting 3.5 × 10⁶ bone marrow (BM) cells from Cry1/2 double-knockout (dKO) or age- and sex-matched wild-type (WT) donors into lethally irradiated CD45.1 recipient mice.
Eight weeks after transplantation, bronchoalveolar lavage (BAL) cells were collected, and RNA-seq was performed to profile transcriptional changes driven by loss of Cry1/2 in the hematopoietic compartment.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313652 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313652 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1380468 ncbi.nlm.nih.gov/bioproject/PRJNA1380468 ↗
project · from NCBI GEO
- PubMed 42239331 pubmed.ncbi.nlm.nih.gov/42239331 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE313652 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |