Omics · study · 2026
Metabolic Programming Promotes Cellular Uptake of Extracellular Vesicles and Boosts In Vivo Therapeutic Efficacy
Listed in NCBI GEO
Extracellular vesicles (EVs) are promising carriers for delivering therapeutic cargos to target cells, yet their in vivo delivery efficacy remains limited despite extensive efforts to optimize their physical and chemical properties.
Description
Recognizing that EV uptake is an interactive process between EVs and cells, we hypothesize that modulating cell states can enhance the uptake and therapeutic impact of drug-loaded EVs. In this study, we investigated how the cellular metabolome influences EV uptake in neuroblastoma cells.
Our results demonstrate that EV uptake varies significantly depending on the cells' metabolic conditions. Through multi-omic analyses, we identified a metabolite cocktail composed of pyruvate and methionine that enhances EV uptake by 150%. In an animal cancer model, co-administration of these metabolite adjuvants markedly reduced the tumor size.
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This work highlights the potential of targeting the cellular metabolome to optimize drug delivery and introduces a straightforward adjuvant strategy to enhance nanoparticle delivery efficacy.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314559 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314559 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1391512 ncbi.nlm.nih.gov/bioproject/PRJNA1391512 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE314559 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |