Text · study · 2026
Il1r1 signaling induces stromal cells reprogramming upon H. pylori infection
Listed in NCBI GEO
Helicobacter pylori infection leads to influx of immune cells in the gastric mucosa, causing chronic inflammation.
Description
Since the mesenchymal niche is known to play a crucial role in the development of infection-associated gastric pathology, we investigate how stromal cells respond to inflammatory triggers, founding that they respond to Il1b and promote epithelial regeneration. To characterize the function of Il1 signaling in stromal cells, we exploit a conditional mouse model that allows the knockout of Il1r1 receptor in the gastric mesenchyme via Col1a2CreErt2:Il1r1 fl/fl.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE283nnn/GSE283927 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE283927 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1196345 ncbi.nlm.nih.gov/bioproject/PRJNA1196345 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE283927 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |