Structure · dataset · 2019
Fabrication of biocompatible porous scaffolds based on hydroxyapatite/collagen/chitosan composite for restoration of defected maxillofacial mandible bone
Listed in ZivaHub and Deakin Research Online — shown once because both records carry DOI 10.26187/deakin.34030032
Fabrication of scaffolds from biomaterials for restoration of defected mandible bone has attained increased attention due to limited accessibility of natural bone for grafting.
Description
Hydroxyapatite (Ha), collagen type 1 (Col1) and chitosan (Cs) are widely used biomaterials which could be fabricated as a scaffold to overcome the paucity of bone substitutes. Here, rabbit Col1, shrimp Cs and bovine Ha were extracted and characterized with respect to physicochemical properties.
Following the biocompatibility, degradability and cytotoxicity tests for Ha, Col1 and Cs a hydroxyapatite/collagen/chitosan (Ha·Col1·Cs) scaffold was fabricated using thermally induced phase separation technique. This scaffold was cross-linked with (1) either glutaraldehyde (GTA), (2) de-hydrothermal treatment (DTH), (3) irradiation (IR) and (4) 2-hydroxyethyl methacrylate (HEMA), resulting in four independent types (Ha·Col1·Cs-GTA, Ha·Col1·Cs-IR, Ha·Col1·Cs-DTH and Ha·Col1·Cs-HEMA).
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The developed composite scaffolds were porous with 3D interconnected fiber microstructure. However, Ha·Col1·Cs-IR and Ha·Col1·Cs-GTA showed better hydrophilicity and biodegradability. All four scaffolds showed desirable blood biocompatibility without cytotoxicity for brine shrimp.
In vitro studies in the presence of human amniotic fluid-derived mesenchymal stem cells revealed that Ha·Col1·Cs-IR and Ha·Col1·Cs-DHT scaffolds were non-cytotoxic and compatible for cell attachment, growth and mineralization. Further, grafting of Ha·Col1·Cs-IR and Ha·Col1·Cs-DHT was performed in a surgically created non-load-bearing rabbit maxillofacial mandible defect model. Histological and radiological observations indicated the restoration of defected bone.
Ha·Col1·Cs-IR and Ha·Col1·Cs-DHT could be used as an alternative treatment in bone defects and may contribute to further development of scaffolds for bone tissue engineering.<p></p>
Links
Where it is published
- DOI doi.org/10.26187/deakin.34030032 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Biomaterials · Biomaterials · Biomedical engineering · Biomedical engineering · Earth & Environmental Science · Earth & Environmental Science · Engineering · Engineering · Life Sciences · Life Sciences · Materials engineering · Materials engineering · Materials Science · Materials Science · Medical biotechnology · Medical biotechnology · Medicine & Health · Medicine & Health · Nanotechnology · Nanotechnology · Regenerative medicine · Regenerative medicine
Provenance · 2 source records, 27 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34030032 | 6 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34030032 | 6 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
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| concepts[field].anzsrc:field:320606 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Regenerative Medicine'] |
| concepts[field].anzsrc:field:320606 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Regenerative Medicine'] |
| concepts[field].anzsrc:field:400302 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['BIOMATERIALS'] |
| concepts[field].anzsrc:field:400302 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['BIOMATERIALS'] |
| concepts[field].anzsrc:group:3206 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Medical biotechnology'] |
| concepts[field].anzsrc:group:3206 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Medical biotechnology'] |
| concepts[field].anzsrc:group:4003 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Biomedical engineering'] |
| concepts[field].anzsrc:group:4003 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Biomedical engineering'] |
| concepts[field].anzsrc:group:4016 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Materials engineering'] |
| concepts[field].anzsrc:group:4016 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Materials engineering'] |
| concepts[field].anzsrc:group:4018 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Nanotechnology'] |
| concepts[field].anzsrc:group:4018 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Nanotechnology'] |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
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| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
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| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |