Liver-specific suppression of PLA2G6/iPLA2β improves glucose and lipid metabolism via phospholipid remodeling in high-fat diet-fed mice

However, its therapeutic effects on metabolic disorders remain elusive. We investigated the effects of Pla2g6 suppression on glucose and lipid metabolism.

Systemic inhibition of Pla2g6 in high-fat diet-fed mice reduced hepatic lipid droplet formation without altering the levels of serum triglycerides and fasting blood glucose. Suppression of liver-specific Pla2g6 utilizing the short-hairpin RNA knockdown technique using an adenovirus vector (Ad-shPLA2G6) altered phospholipid and fatty acid metabolites and suppressed hepatic lipid accumulation, serum triglyceride, fasting glucose, and insulin levels.