Genetic Deletion of the Inflammatory Bowel Disease -Associated Risk Gene Rgs14 Aggravates Experimental Colitis

Of the twenty RGS, Rgs14 single-nucleotide polymorphism is associated with inflammatory bowel disease. This manuscript describes a novel conditional mouse line that allows deletion of Rgs14 in defined cell lines.

We show that deletion of Rgs14 in macrophages affects macrophage function and aggravates colitis severity. This novel conditional mouse model will help to investigate further the function of Rgs14 for inflammatory bowel disease and possibly other conditions, such as metabolism, neuroscience, and aging