Omics · study · 2026
RNA-Seq analysis TMAO effect on vascular smooth muscle cells
Listed in NCBI GEO
Thoracic aneurysm/dissection (TAAD) is a life-threatening condition that lacks effective pharmacotherapeutic treatment.
Description
Vascular smooth muscle cells (VSMCs) phenotype switch and extracellular matrix (ECM) degradation has been thought to be critical to the development of TAAD. Trimethylamine N-oxide (TMAO), a metabolite produced by gut microorganisms, is tied with various risk factors for cardiovascular disease, however direct correlation with TAAD remains elusive.
RNA-seq analysis TMAO targets identified a cohort of genes, critically involved in the ECM signaling.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE226nnn/GSE226668 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE226668 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA941203 ncbi.nlm.nih.gov/bioproject/PRJNA941203 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cardiovascular disease 75% · Disease 75% · RNA sequencing 65%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE226668 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cardiovascular-disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |