Omics · study · 2026
Study of gene expression in mouse primary hepatocytes cultured in hydrogels with different stiffnesses in wild-type and YAP/TAZ knockout.
Listed in NCBI GEO
Liver stiffness is extensively utilized as a crucial indicator in the diagnosis and monitoring of MASLD, the contribution of increased stiffness on impaired liver functions and its molecular mechanisms remains poorly understood.
Description
Wild-type or Yap/Taz knock-out hepatocytes were cultured on soft (1 kPa) and stiff (20 kPa) hydrogels to embody healthy and fibrotic livers and subjected to metabolomic and transcriptomic analyses.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE274nnn/GSE274047 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274047 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1144779 ncbi.nlm.nih.gov/bioproject/PRJNA1144779 ↗
project · from NCBI GEO
- PubMed 41747066 pubmed.ncbi.nlm.nih.gov/41747066 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE274047 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |