Omics · study · 2026
Patients who received abatacept for graft versus host disease prophylaxis have lower peri-engraftment NETosis and less endothelial injury
Listed in NCBI GEO
Abatacept decreases risk of aGVHD in adult and pediatric patient populations, but its effect on other clinical outcomes of HSCT has not been well studied.
Description
Abatacept’s effect in reducing GVHD has been linked to T-cell dependent mechanisms, but it’s effect on neutrophils and completement activation is largely unknown. In this study we analyzed the effect of abatacept prophylaxis in clinical outcomes of HSCT and explored other potential mechanisms.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE283nnn/GSE283630 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE283630 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1194644 ncbi.nlm.nih.gov/bioproject/PRJNA1194644 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE283630 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |