Constarium
← Search

Omics · study · 2026

Effect of CST3 knockout on gene expression in THP-1-derived macrophages

Listed in NCBI GEO

To systematically investigate the biological role of CST3 in macrophages, we performed RNA-seq on THP-1-derived macrophages from wildtype (CST3+/+) and CST3 knockout (CST3-/-) backgrounds.

Description

Comparative transcriptomic analysis revealed differential expression of genes involved in inflammatory response upon CST3 loss. These findings provide a comprehensive resource for understanding the molecular mechanisms by which CST3 regulates macrophage phenotype and function, with potential implications for inflammatory diseases and immune modulation.

Links

Get the data

Where it is published

Documentation and papers

Topics

Stated by source
Expression profiling by high throughput sequencing · Homo sapiens
From keywords
Life Sciences
Inferred from text
RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE31852712 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (65%)
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title