Imaging · study · 2026
Spatial transcriptomic analysis of patient- and cell line-derived high grade serous ovarian cancer spheroids
Listed in NCBI GEO
In vitro models of high grade serous ovarian cancer spheroids are often used to study mechanisms of cell dormancy and resistance to chemotherapy, but their ability to accurately mimic spheroid biology in patients is unclear.
Description
We performed spatial transcriptomic profiling of in vitro cell line- and in vivo patient-derived high grade serous ovarian cancer spheroids to profile spheroid cell composition and gene expression programs between models.
Our analysis reveals the predominant cell types that make up patient spheroids and common expression patterns that shared between models.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335181 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335181 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1477545 ncbi.nlm.nih.gov/bioproject/PRJNA1477545 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE335181 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |