Data · dataset · 2024
Single-cell Transcriptome Data of Mouse Thymus
Listed in ScienceDB
The thymus plays a crucial role in the development and maintenance of the immune system by facilitating the maturation of T cells.
Description
Age-related thymic involution leads to a decline in immune function, contributing to increased susceptibility to infections and diseases in the elderly. However, the cellular mechanisms underlying thymic aging and involution are not fully understood.
In this study, we performed single-cell RNA sequencing (scRNA-seq) on thymic tissues from young (4-week-old, BO611-007X0001, BO611-007X0002, BO611-007X0003) and aged (52-week-old, BO611-007X0004, BO611-007X0005, BO611-007X0006) C57BL/6J mice, with three biological replicates per age group. Our dataset provides a comprehensive single-cell atlas of the thymus across different ages, revealing changes in cell types and their abundances associated with aging.
Read the rest (1 more)
This resource offers valuable insights into the cellular heterogeneity of the thymus and lays the groundwork for further research into the mechanisms of immune aging and potential therapeutic interventions.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.18162 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.18162 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[modality].local:modality:rna-seq | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |