Table · dataset · 2026
Table 1_A bespoke non-invasive approach to predict fetal genotype in pregnancy.docx
Listed in HKU DataHub and figshare and Loughborough Research Repository — shown once because both records carry DOI 10.3389/fmed.2026.1745404.s001
Introduction<p>The fetal genome influences fetal growth; however, it is currently not used to customize fetal growth charts due to the need for invasive testing.
Description
Total cell-free-DNA (T-cfDNA) from maternal blood during pregnancy contains maternal-cfDNA and fetal-cfDNA. T-cfDNA offers the opportunity to non-invasively determine fetal single nucleotide polymorphisms (SNPs).
This study aimed to determine the feasibility of genotyping fetal SNPs in pregnancy using parental genomic-DNA (gDNA) and maternal T-cfDNA, and computing fetal polygenic scores (PGS) as proxies for several health domains.</p>Methods<p>Parental and cord blood gDNA, and maternal T-cfDNA were collected. Genotyping was performed using Illumina Global Screening Array. Signal intensity parameters (SIPs) were extracted for genotyped SNPs.
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Fetal SNPs were predicted using corresponding paired parental SNPs when both parents were homozygous, and from maternal gDNA SIP confidence intervals otherwise. Six PGSs for phenotypes including birthweight-PGS were computed using predicted fetal SNPs. Predictions were verified against genotyped cord blood.</p>Results<p>The average fetal SNP prediction accuracy was 86.39% (95% CI: 85.94-86.84%).
Improved performance was observed when computing PGSs with a greater number of SNPs; coefficient of variation ranged from 5.6-16.5%.</p>Discussion<p>Results suggested moderate predictive performance. Improvements in the accuracy of SNP prediction are needed before clinical implementation. This may be through advanced bioinformatics methods or genotyping methodology.</p>
Links
Where it is published
- DOI doi.org/10.3389/fmed.2026.1745404.s001 ↗
DOI / persistent id · from datahub hku hk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from datahub hku hk
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Foetal development and medicine · Foetal development and medicine · Foetal development and medicine · Humanities · Humanities · Life Sciences · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science
- Inferred from text
- Tabular 65%
Provenance · 3 source records, 35 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| HKU DataHub | oai:figshare.com:article/34009665 | 10 d ago | JSON v1 |
| figshare | oai:figshare.com:article/34009665 | 9 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/34009665 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].anzsrc:field:321501 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Foetal Development and Medicine'] |
| concepts[field].anzsrc:field:321501 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Foetal Development and Medicine'] |
| concepts[field].anzsrc:field:321501 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Foetal Development and Medicine'] |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[modality].local:modality:tabular | enrichment · datahub hku hk | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/description |
| license | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/rights |
| publication_date | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| title | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/title |