Omics · study · 2026
Peripheral serotonin regulates epidermal differentiation and dermal homeostasis
Listed in NCBI GEO
Serotonin is a neurotransmitter with key peripheral functions including regulation of vascular tone, immune responses and tissue repair.
Description
It has been shown that it is expressed in skin but its role in skin homeostasis remains unclear. We conducted transcriptomic analyses to elucidate the effects of serotonin deficiency on epidermal and dermal compartments using tryptophan hydroxylase 1 knockout mice.
Our results revealed that peripheral 5-HT plays a role in epidermal differentiation, barrier integrity and homeostasis of the dermal compartment.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326714 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326714 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1446790 ncbi.nlm.nih.gov/bioproject/PRJNA1446790 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326714 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |