Omics · study · 2026
Transcriptomic analysis of human small intestinal organoids (hSIOs) from PiMM and PiZZ patients
Listed in NCBI GEO
Transcriptomic analysis was performed on human small intestinal organoids (hSIOs) generated from induced pluripotent stem cells (iPSCs) from PiMM and PiZZ patients.
Description
This analysis revealed that accumulation of mutant Z alpha1 antitripsin in intestinal cells induces activation of pathways related to stress, including protein processing in ER and immune response, while dowregulates the expression of genes related to cell cycle, DNA repair, and stemness.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE291nnn/GSE291018 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291018 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1231411 ncbi.nlm.nih.gov/bioproject/PRJNA1231411 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE291018 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |