Omics · study · 2026
Effect of overexpression of DDX17(P82) on gene expression in LIM1215 cells
Listed in NCBI GEO
DEAD-box helicase 17 (DDX17), known to exist as two isoforms, p72 and p82, is a member of the DEAD-box family.
Description
In addition to serving as an RNA helicase, DDX17 also plays an essential role in transcriptional regulation. Here, we report that the overexpression of DDX17 (P82) promotes the expression of JAK-STAT pathway–related genes.
Moreover, DDX17 (P82) forms phase-separated droplets with SP1 in the nucleus, which enhances the transcriptional activity of the target genes, driving cetuximab resistance in colorectal cancer (CRC).
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326566 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326566 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1445907 ncbi.nlm.nih.gov/bioproject/PRJNA1445907 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326566 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |