Omics · study · 2026
RNA-Seq analysis of tumor and matched normal samples from colorectal cancer patients.
Listed in NCBI GEO
Tumour cells often downregulate human leukocyte antigen (HLA) class I to evade cytotoxic T lymphocyte (CTL) immunity.
Description
Although natural killer (NK) cells target MHC-I-deficient cells, many cancers bypass NK cell-mediated killing through additional immune evasion strategies. Using CRISPR-Cas9 screening, GPC2, a cell surface protein, was identified as a key suppressor of NK cell activity against HLAnull cancer cells.
GPC2 is upregulated in several cancers, correlating with poor patient outcomes. In colorectal cancer, GPC2 was found to be inversely correlated with HLA class 1 expression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE292nnn/GSE292858 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292858 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1241760 ncbi.nlm.nih.gov/bioproject/PRJNA1241760 ↗
project · from NCBI GEO
- PubMed 41803264 pubmed.ncbi.nlm.nih.gov/41803264 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE292858 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |