Unraveling the Epigenetic Landscape of Sarcopenic Obesity: Insights into DNA Methylation Mechanisms from a Pilot Study in Older Women

When these two conditions coexist, the result is sarcopenic obesity (SO), a functional and clinical condition characterized by excess fat mass and reduced muscle mass and function. Although cross-talk between muscle and fat tissue is thought to play a central role in SO pathophysiology, the epigenetic mechanisms involved remain poorly understood.

Thus, this study aimed to investigate whole-blood DNA methylation patterns in older women with sarcopenic obesity, obesity, sarcopenia, and normal weight, as well as to explore the associated signaling pathways.