Omics · study · 2026
Betulonic acid alleviates dexamethasone-induced MC3T3-E1 osteoblast injury: a transcriptomic sequencing analysis
Listed in NCBI GEO
Steroid-induced osteonecrosis of the femoral head(SONFH) is a severe complication of glucocorticoid therapy, with oxidative stress playing a pivotal role in its pathogenesis.
Description
Betulonic acid (BA), a natural triterpenoid, exhibits antioxidant properties; however, its role in SONFH remains unclear. This study aimed to investigate the protective effect of BA against dexamethasone (DEX)-induced osteoblast injury and its underlying molecular mechanisms.Three experimental groups were established: control (NC), dexamethasone treatment group(DEX), and dexamethasone plus BA co-treatment group(DEX_BA), each with three biological replicates.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312690 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312690 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1375725 ncbi.nlm.nih.gov/bioproject/PRJNA1375725 ↗
project · from NCBI GEO
- PubMed 42703376 pubmed.ncbi.nlm.nih.gov/42703376 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE312690 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |