Omics · study · 2026
Transcriptome analysis of tumor tissues dervied from lung cancer patients
Listed in NCBI GEO
The prognosis of non-small cell lung cancer (NSCLC) with leptomeningeal metastases (LM) is dismal.
Description
The regulators of LM progression remain elusive, thus impeding effective clinical intervention. Here, we performed transcriptome analysis of the molecular features of tumor tissues dervied from leptomeningeal-metastatic lung cancer patients.
In patients with NSCLC, FUS downregulation and CD36 or SYP upregulation were associated with aggressive LM progression. CD36-mediated fatty acid metabolism and NED signature are crucial for LM progression in NSCLC, highlighting CD36 as a potential LM biomarker and a promising therapeutic target for LM treatment.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337540 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337540 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1490243 ncbi.nlm.nih.gov/bioproject/PRJNA1490243 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE337540 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |