Omics · study · 2026
PHLDA2 promotes breast cancer metastasis by increasing extracellular matrix deposition and vascular permeability
Listed in NCBI GEO
There is a critical need to define drivers of metastasis in order to identify novel drug targets and improve patient prognosis.
Description
These are particularly necessary for receptor negative Triple Negative Breast Cancer (TNBC) for which there are no targeted therapy options. Our previous work identified a potential breast cancer metastasis promoting gene known as Pleckstrin-Homology like Protein 2, PHLDA2.
In this study, we define the novel role of PHLDA2 as a pro-metastatic gene in TNBC and investigate its mechanism. Bulk sequencing of TNBC cells overexpressing PHLDA2 reveal upregulation of genes related to cell migration, extracellular matrix deposition, and vascular permeability. We validate these bulk sequencing results using in vitro and in situ assays.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE279nnn/GSE279530 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE279530 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1173201 ncbi.nlm.nih.gov/bioproject/PRJNA1173201 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE279530 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |