Omics · study · 2026
An aging-sensitive compensatory neuroprotective factor that confers cognitive resilience
Listed in NCBI GEO
Endogenous compensatory changes influence trajectory of brain aging, cognitive decline and Alzheimer’s Disease (AD) risk, however, the identities of underlying mechanisms have remained elusive.
Description
A screen for hippocampal dentate granule cell (DGC) synapse loss-induced factors identified a secreted phospholipase, Pla2g2f, whose expression increases in DGCs during aging. Pla2g2f deletion in DGCs exacerbates aging-associated synapse loss, emergence of inflammatory microglia, reactive astrogliosis, lipid dysregulation and memory impairment.
Boosting Pla2g2f in DGCs during aging prevents these pathophysiological impairments and modifies trajectory of cognitive decline. In human microglia-neuron coculture experiments PLA2G2F mediates intercellular signaling to decrease lipid burden. Boosting Pla2g2f expression in an aging-sensitive AD model reduces amyloid load and preserves memory.
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Thus, PLA2G2F functions as a compensatory neuroprotective factor that counteracts aging-associated cognitive decline.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE261nnn/GSE261906 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE261906 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1089560 ncbi.nlm.nih.gov/bioproject/PRJNA1089560 ↗
project · from NCBI GEO
- PubMed 39211220 pubmed.ncbi.nlm.nih.gov/39211220 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE261906 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |