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Omics · study · 2026

Transcriptome regulation in iPSC and astrocyte derived from CLN3 deficient patient

Listed in NCBI GEO

CLN3 Batten disease is a severe pediatric neurodegenerative disorder caused by mutations in the CLN3 gene, most commonly a 1 kb deletion affecting exons 7 and 8.

Description

While research has focused on neuronal dysfunction, glial cells are increasingly recognized as key contributors to disease pathology. Here, we establish the iPSC and astrocyte model derived from a CLN3 patient fibrpblast cells with the 1 kb deletion and analyse the transcriptome regulation in both iPSC and astrocyte stages.

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Expression profiling by high throughput sequencing · Homo sapiens
From keywords
Life Sciences
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Disease 75%
Provenance · 1 source records, 8 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE29962215 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:diseaseenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title